I had a problem in version “22.214.171.124” of OD. I was unable to upload packages because of this error listed below. It was fixed by restarting the box. But reproducible by deleting all the packages from the feed.
2014-05-19 15:33:24.7681 ERROR Unhandled error on request: http://octopus/nuget/packages/ : Access to the path 'D:\Octopus\OctopusServer\Repository\Packages\Package.Name' is denied. System.UnauthorizedAccessException: Access to the path 'D:\Octopus\OctopusServer\Repository\Packages\Package.Name' is denied. at Microsoft.Runtime.CompilerServices.TaskAwaiter.ThrowForNonSuccess(Task task) at Microsoft.Runtime.CompilerServices.TaskAwaiter.HandleNonSuccess(Task task) at Microsoft.Runtime.CompilerServices.TaskAwaiter`1.GetResult() at NuGet.Lucene.LucenePackageRepository.<AddPackageAsync>d__5.MoveNext()